• Introduction Stroke remains a leading cause of adult disabil

  2018-10-22

  

  Introduction Stroke remains a leading cause of adult disability worldwide. In Brazil it is the leading cause of death, with a mortality rate of approximately 51.6 deaths per 100,000 inhabitants (Garcia et al., 2009) and shows the highest case-fatality rate in Latin America (Lotufo and Bensenor, 200

• In the present study we used an in vitro model

  2018-10-22

  

  In the present study, we used an in vitro model system to observe the changes of phenotypic fate of astrocytes under different treatments. These data indicate that the elevation of Shh production in mechanically-insulted astrocytes plays a crucial role in the de-differentiation of astrocyte as Shh b

• To define the transcriptome of the ExE

  2018-10-22

  

  To define the transcriptome of the ExE lineage in the present study, we analyzed primitive endoderm and trophectoderm markers using qRT-PCR. Interestingly, we found that markers of the primitive endoderm, such as DDAH2, LAMB1, DAB2, AFP and NR2F1 (COUP-TF1), and markers of the trophectoderm, such as

• br Results br Discussion Recent advances

  2018-10-22

  

  Results Discussion Recent advances enabling the prospective isolation of mouse satellite ion channel have facilitated mechanistic analyses of their myogenic function. For example, the ability to clonally sort satellite cells with high purity made possible the demonstration that these cells ca

• To stage rhesus and human PGCs we

  2018-10-22

  

  To stage rhesus and human PGCs, we created a heatmap of diagnostic genes that represent early PGCs (prior to DAZL and VASA expression), late PGCs (DAZL and VASA positive but prior to the emergence of major sex-specific transcriptional differences), advanced PGCs (enrichment of the male-specific gene

• We found that the developmental stage of

  2018-10-22

  

  We found that the developmental stage of transplanted RPESC-RPE influenced preservation of vision but not preservation of photoreceptor cells. Although the underlying explanation for this divergence is unknown, one possibility is that the developmental stage influences (±)-Nutlin-3 more than rods.

• Besides the production of transgenic spermatozoa

  2018-10-22

  

  Besides the production of transgenic spermatozoa and animal production, studies using in vitro maintained spermatogonial stem Sulfo-NHS-Biotin are important to identify the mechanism of spermatogenesis in mammals, facilitate research on male infertility, and disseminate the genetics of animal produ

• br Acknowledgments This work was funded by grants from

  2018-10-22

  

  Acknowledgments This work was funded by grants from the Institut de Recherche sur la Moelle épinière et sur l\'Encéphale (IRME), and the Agence Nationale de la RechercheANR-09-MNPS-027-01 (to A.G); FEDER N°33552 and the CPER 5. B.S. is a postdoctoral fellow of ANR. We thank Dr. André Goffinet for

• The underlying justification for such adipose derived proced

  2018-10-20

  

  The underlying justification for such adipose-derived procedures is the assumption that the cellular extract contains mesenchymal stem atm kinase inhibitor (MSCs) — a type of stromal cell isolated from a wide variety of sources including bone marrow, fat, dental pulp and placental tissue and one of

• br Mechanisms of cardiomyocyte regeneration pose challenges

  2018-10-20

  

  Mechanisms of cardiomyocyte regeneration pose challenges for investigation Cardiomyocyte generation in the adult mammalian heart is a slow process compared with the blood, skin, and the digestive system, which makes it difficult to characterize turnover dynamics. In situ time lapse imaging of the

• br Materials and methods br Results br

  2018-10-20

  

  Materials and methods Results Discussion Obesity results when caloric intake exceeds energy expenditure, with an increase in adipocyte size or adipocyte number (Bjorntorp, 1974; Faust et al., 1978; Johnson et al., 1971, 1978; Yu et al., 1997). In the context of adipogenesis, development app

• A few studies have characterized abnormalities of

  2018-10-20

  

  A few studies have characterized abnormalities of the BM microenvironment in hematologic malignancies. Some reported that BMSCs in MDS are cytogenetically and functionally normal and maintain their original function of supporting normal hematopoiesis (Flores-Figueroa et al., 2008; Klaus et al., 2010

• The goal of this study was

  2018-10-20

  

  The goal of this study was to identify an additional cell-surface marker that, when combined with CD133, could further distinguish and enrich PCFUs. Cell surface markers that were previously known to enrich non-pancreas progenitor cells, including CD71 (transferrin receptor), were screened. CD71 tra

• To the best of our knowledge

  2018-10-20

  

  To the best of our knowledge, this is the first study to characterize H3K27me3 and H3K4me3 re-patterning accompanying cardiac reprogramming. Recently, it was reported that iPSC reprogramming is characterized by global loss of H3K27me3 in the beginning and later restoration of H3K27me3 at selected si

• AL 8697 br Mat http www RO

  2018-10-20

  

  Material andmethods Results anddiscussion Conclusions Here we report a comprehensive and unique transcriptomic study of the kinetics of gene AL 8697 during ASC adipogenesis in vitro. Despite the limitation of the study design including the use of relatively late passage ASCs and the lack of

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