• In our studies the EC values

  2022-02-22

  

  In our studies, the EC50 values for long-chain unsaturated fatty acids added to the short form of human GPR120 receptor (BC101175), were higher than the EC50 values previously reported (Hirasawa et al., 2005) for the long form of GPR120 (NM_181745), which was co-expressed with Gα16 protein.(Table 2)

• br Discussion Naloxone and CTAP were

  2022-02-22

  

  Discussion Naloxone and CTAP were able to alter the febrile response induced by gp120. This effect was particularly evident during the initial hours following gp120 administration (90–210min). We also investigated the potential role of the delta-2 opioid receptor in gp120-induced fever. The delta

• Overall our results indicated the involvement

  2022-02-22

  

  Overall, our results indicated the involvement of GABAAR in controlling GnRH/LH release through mechanism which included GABA action on molecular processes leading to GnRH biosynthesis. This is consistent with previous in vivo [14,54] and in vitro [55] studies in ewes suggesting that GABA inhibits G

• br Introduction Verticillium dahliae Kleb is

  2022-02-22

  

  Introduction Verticillium dahliae (Kleb.) is a soil-borne fungal pathogen that is able to infect hundreds of plant species, and causes vascular wilt disease [1], [2]. In nature, the infection of V. dahliae initiates from the germination of resting structures called microsclerotia [3]. The germina

• One of the main clinical issues

  2022-02-22

  

  One of the main clinical issues of ABCB1, together with its impact on intestinal absorption, concerns its location at the BBB. Indeed, ABCB1 has been identified in the luminal side of endothelial cells and in the abluminal side of astrocyte endfeet processes of the CNS microvasculature [[36], [37],

• br Conclusion Until recently astrocytes were recognized sole

  2022-02-22

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of Annexin V-Cy5 Apoptosis Kit homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission.

• To further implicate the role of

  2022-02-22

  

  To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 Fructose Colorimetric/Fluorometric Assay Kit synthesis was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA b

• br Materials and methods br Results br Discussion The

  2022-02-22

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast eicosapentaenoic acid by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs withi

• br Genetic rescue of GluR A dependent

  2022-02-22

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific Autophagy Compound Library of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt

• br Materials and methods br Acknowledgments

  2022-02-22

  

  Materials and methods Acknowledgments Introduction Gentiooligosaccharides are novel functional oligosaccharides composed of glucose units linked through β-1,6 glycosidic bonds, examples of which include gentiobiose, gentiotriose and gentiotetraose (Barreteau et al., 2006, Kim et al., 2003,

• To confirm the in vitro

  2022-02-22

  

  To confirm the in vitro findings, atorvastatin or pravastatin was given to C57BL6/J mice fed with high fat diet. Doses of atorvastatin were set to be 6 mg/kg and 12 mg/kg, which were within clinical therapeutic doses. The results revealed that treatment of atorvastatin but not pravastatin impaired g

• Fig A demonstrates the body weight gain

  2022-02-22

  

  Fig. 2A demonstrates the body weight gain of the pregestational females. High-fat diet in wild-type mice increased body weight in 2 weeks and sustained this increase over 8 weeks. A similar effect was noted in glut3 mice in response to a high-fat diet. Fig. 2B depicts fat and muscle mass as assessed

• The role of the ER EK variant which is

  2022-02-22

  

  The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of Deferasirox levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might protect from t

• Herein we report the discovery of

  2022-02-21

  

  Herein, we report the discovery of AM-3189 (). AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. As we reported previously, activity on the GPR40 receptor varies significantly with substitution at the β-carbon relative to

• Levonorgestrel australia In addition the interplay of

  2022-02-21

  

  In addition the interplay of membrane curvature induced tension at the fusion pore and Levonorgestrel australia induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warr

16166 records 497/1078 page Previous Next First page 上5页 496497498499500 下5页 Last page